Clinical cohorts

As a translational lab, we utilize a number of clinical cohorts that help us investigate the pathophysiology of cardiometabolic disease.

Project Title	Cohort Acronym	Ethical Approval	clinicaltrials.gov
Cardio-metabolic health and inflammatory resolution	REX	Dnr 2019-04179	NCT04256330
Inflammation and obesity-related disease	Adipos2	Dnr 682-14	NCT02322073
Adipose tissue inflammation and diabetes	FAB	Dnr 2019-04046	NCT04255264
The role of inflammation in vascular disease	REBEL	Dnr 660-18	NCT03732612
Correlation of clinical parameters in metabolically healthy and diseased gastric bypass patients	TESLA	Dnr 792-18	N/A

REX Cohort

The REX study is an ERC StG supported project. We collaborate with Prof Göran Bergström and SCAPIS Gothenburg to identify subjects of known cardiometabolic phenotypes. Subsequently, those interested in volunteering as study participants are invited to the lab where we assess their inflammatory profile through a range of pre-clinical tests and basic molecular biology techniques

PI: Emma Börgeson
Co-PI: Göran Bergström
MD: Per-Anders Jansson

Adipos2 Cohort

In the Adipos2 study, we investigate tissue inflammation. Volunteer patients that are either lean (undergoing gallbladder removal surgery) or obese (undergoing gastric bypass surgery) donate small fat and liver biopsies. In addition we biobank blood, saliva and urine samples and take a detailed medical history.

PI: Ville Wallenius
Co-PI: Emma Börgeson
MD: Ville Wallenius

FAB Cohort

In the FAB study, the whole lab comes together to biobank the substantial amounts of tissues donated by volunteer patients undergoing abdominoplasty surgery. The unique aspect of this cohort is that the patients undergoing surgery has a BMI between 30-40 kg/m2, which is unusual as abdominoplasty is most commonly only performed on patients that have a BMI under 30 kg/m2. In this study, volunteer patients donate the tissues that are normally discarded during surgery. In addition, we biobank blood samples and take a detailed medical history. The tissues are used for numerous research project, but a key aspect is the biobanking of hundreds of vials of human primary pre-adipocytes. This is done in collaboration with Dr. Jeremie Boucher and AstraZeneca and the cells that can readily be differentiated to human adipocytes ex vivo, thus providing a valuable cell culture model that the lab utilizes extensively.

PI: Emma Börgeson
MD: Trude Staalesen

REBEL Cohort

In the REBEL study we investigate inflammation in the blood vessels. Volunteer patients donate blood and vessel tissue, that would otherwise be discarded after surgery. In addition we biobank blood samples and take a detailed medical history. We include both patients that are healthy and those with atherosclerotic manifestation.

PI: Emma Börgeson
MD: Per Skoog

TESLA Cohort

In the TESLA-1 study we collaborate with a bariatric surgery clinic headed by Prof van der Merwe and Dr Fetter at CEMMS Waterfall City Hospital, Johannesburg, South Africa. By obtaining clinical parameters before and after gastric bypass surgery, we research how weight loss impacts the metabolic phenotype of those patients that choose to participate.

PI: Emma Börgeson
MD: Tess van Merwe